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KMID : 1035620140020020108
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Allergy Asthma & Respiratory Disease
2014 Volume.2 No. 2 p.108 ~ p.113
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The effect of atopy and allergic diseases on pulmonary function of Korean adolescents
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Hwangbo Jun-Won
Kwon Ji-Won
Kim Woo-Kyung
Kim Hyung-Young
Kim Hyo-Bin
Seo Ju-Hee
Song Dae-Jin
Shim Jung-Yeon
Yu Jin-Ho
Lee So-Yeon
Jang Gwang-Cheon
Hong Soo-Jong
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Abstract
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Purpose: Pulmonary function test (PFT) plays a key role in the diagnosis and management of asthma in adolescents. But, it is not clear whether adolescents with asthma have significantly reduced lung function when compared with adolescents without asthma. The purpose of this study was to determine the effect of atopy and allergic diseases on pulmonary function and bronchial hyperresponsiveness (BHR) in Korean adolescents.
Methods: A questionnaire survey was conducted on 647 middle school students (male, 264; female, 383) from Seoul city to determine the prevalence of symptoms and diagnosed allergic diseases. We also performed the PFT, methacholine challenge test, skin prick tests and serum total immunoglobulin E. Current atopic dermatitis was diagnosed by doctor’s medical examination.
Results: Female showed higher values of forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) and higher numbers of BHR (PC20 less than 25 mg/dL) compared to male (P<0.01). BHR was more common in atopy group (P<0.01), but PFT was not significant difference between atopy and nonatopy. Mean values for all spirometric parameters for asthmatic adolescents were in the normal range. Adolescents with asthma symptoms had slightly lower FEV1/FVC and forced expiratory flow 25%-75% than that of adolescents with no history of wheeze ever, asthma diagnosis and current asthma, but there was no statistically significance.
Conclusion: The majority of adolescents recruited from the general population who reported having asthma symptoms or other allergic diseases had normal lung function. Sex, atopy, and current atopic dermatitis may affect BHR in Korean adolescents
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KEYWORD
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Pulmonary function test, Bronchial hyperresponsiveness, Asthma, Sinusitis
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